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GPAT 2018 Syllabus

  GPAT syllabus include the questions of Bachelor of Pharmacy (B.Pharm) level. The subjects covered under the syllabus are Physical Chemistry, Physical Pharmacy, Organic Chemistry, Pharmaceutical Chemistry, Pharmaceutics, Pharmacology, Pharmacognosy, Pharmaceutical Analysis, Biochemistry, Biotechnology, Microbiology, Pathophysiology, Biopharmaceutics and Pharmacokinetics, Clinical Pharmacy  and Therapeutics, Anatomy, Physiology and Health Education, Pharmaceutical Engineering, Pharmaceutical Management, Dispensing and Hospital Pharmacy. The detailed syllabus will be provided when it will be released by the authority.

AICTE (All India Council for Technical Education) conducts national level examination GPAT (Graduate Pharmacy Aptitude Test) to offer admission to eligible applicants in Master’s degree in Pharmacy known as MPharma. The examination will be scheduled in the 3rd week of January 2018. The applicants are advised to go through the eligibility criteria before they start the application process. GPAT score is being used by all AICTE approved Institutions/University Departments and Constituent Colleges. In the field of Pharmacy, scores are also considered for providing scholarships and other financial assistance. Candidates can check details about GPAT 2018 Syllabus in this article.

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GPAT 2018 Syllabus

  • The examination syllabus will be prescribed by AICTE for GPAT 2018 Syllabus.
  • GPAT syllabus includes the questions of Bachelor of Pharmacy (B.Pharm) level.
  • The subjects covered under the syllabus are Organic Chemistry, Pharmaceutical Chemistry, Pharmaceutics, Pharmacology, Physical Chemistry, Physical Pharmacy, Pharmacognosy, Pharmaceutical Analysis, Biochemistry, Pathophysiology, Biopharmaceutics, Biotechnology, Microbiology, Pharmacokinetics, Clinical Pharmacy and Therapeutics, Anatomy, Pharmaceutical Engineering, Dispensing and Hospital Pharmacy, Pharmaceutical Management, Physiology and Health Education.


  • Composition & physical states of matter Intermolecular forces & their impact on state of the matter.
  • Various physical properties of matter, dipole moment, dielectric constant, Van Der waal’s equation & critical phenomenon, liquefaction of gases, aerosols.
  • Colligative Properties The liquid state, vapor pressure, ideal & real solutions. Raoult’s law, elevation of boiling point, depression of freezing point, osmotic pressure, determination of molecular weight based on colligative properties.
  • Thermodynamics First, second & third law of thermodynamics. Thermochemical laws, isothermic & adiabetic processes, reversible processes, work of expansion, heat content, enthalpy, heat capacity. Gibb’s & Helmoltz equation & chemical potential.
  • Chemical Equillibria.
  • Phase rule One, two, & three component systems along with their applications. Solid- solid, solid – liquid, & liquid-liquid systems. Distillation of binary systems, azeotropic mixtures, steam, vacuum, & fractional distillation.
  • Refractive index Refractive index, specific refractivity, molar refractivity, refractometers.
  • Solutions Solubility, factors affecting solubility, solubility curves. Types of solutions, effect of cosolvancy, pH & other factors on solubility. Solubility of gases in liquids, liquids in liquids, & solids in liquids, critical solution temperature, law of partitioning & its applications. Solute solvent interactions. Expression of concentration of pharmaceutical solutions & calculations. Molarity, molality, mole fraction & percentage expressions.
  • Electrochemistry Properties of electrolyte solutions, electrolysis. Faraday’s law of electrolysis, electron transport, electrical cell, single electrode potential, concentration cells, half-cells & half cell potential, types of half cells, sign convention, Nerst equation, salt bridge, electromotive series, standard potential, SHE. Measuring the relative voltage of half cells, Calculation of standard potential. Reference & indicator electrodes. Standard oxidation-reduction potential.


  • Matter, properties of matter States of matter, change in the state of matter, latent heat and vapor pressure, sublimation-critical point, eutectic mixtures, gases, aerosols- inhalers, relative humidity, liquid complexes, liquid crystals, glasses state, solid crystalline and amorphous polymorphism.
  • Micromeritics and powder rheology Particle size and distribution, average particle size number and weight distribution, particle number, method of determining particle size and volume, optical microscopy, sieving, sedimentation, determining surface areas, permeability, adsorption, derived properties of powders, porosity, packing arrangement densities, bulkiness and flow properties.
  • Surface and interfacial phenomenon Liquid interface, surface and interfacial tensions, surface free energy, measurement of surface and interfacial tension, spreading coefficient, adsorption and liquid interfaces, surface active agents, HLB classification, solubilization, detergency, absorption at solid interfaces, solid gas and solid liquid interfaces, complex films, electrical properties of interfaces.
  • Viscosity and rheology Newtonian systems, law of flow, kinematics viscosity, effect of temperature, non Newtonian systems, pseudoplastics, dilatant, plastic, thixotropy in formulations, determination of viscosity and thixotropy by capillary, falling ball, rotational viscometer, application of theology in pharmacy.
  • Dispersion systems a. Colloidal dispersions: Definition, types, properties of colloids, protective colloids, application of colloids in pharmacy. b. Suspensions and emulsions: Interfacial properties of suspended particles settling in suspension, theory of sedimentation, effect of Brownian movement, sedimentation of flocculated particles, sedimentation parameters, wetting of particles, significance of electrical properties in dispersions, controlled flocculation, flocculation in structured vehicles, rheological considerations, emulsions: types, theories, physical stability.
  • Complexation Classification of complexes, methods of preparations and analysis, applications.
  • Buffer Buffer equations and buffer capacity in general. Buffers in pharmaceutical systems,preparations and stability, buffered isotonic solutions. Measurements of tonicity calculations and methods of adjusting isotonicity.


  • General principles A brief review of classification & sources of organic compounds, sp3, sp2, sp hybridization, sigma & pi- bonds, bond lengths, bond angles & bond energies along with their significance in reactions should be carried out. An overview of bond polarization, hydrogen bonds, inductive effects, resonance, and hyper conjugation be taken. Concept of homolytic & heterolytic bond fission, acidity & basicity with different theories should be covered briefly. Ease of formation & order of stabilities of electron deficient & electron rich species along with the reasons for the same should be covered. Relationships between energy content, stability, reactivity & their importance in chemical reactions should be covered. Calculations for determining empirical & molecular formula should be covered.
  • Different classes of compounds The following classes of compounds should be taught in detail with respect to their IUPAC / systematic nomenclature, industrial [wherever applicable] & laboratory methods of preparations, physical properties & chemical reactions with emphasis on reaction mechanisms [arrow based] & stereochemistry [wherever applicable]. • Alkanes [including cyclic compounds] • Alkenes [including cyclic compounds] • Alkynes [only open chain compounds] • Aliphatic hydroxyl compounds • Alkyl halides • Aldehydes & ketones • Carboxylic acids • All functional derivatives of carboxylic acids.
  • Protection & deprotection of groups Introduction to protection & deprotection of functional groups. Two examples each for amino, hydroxyl, & carbonyl groups. The significance of these in syntheses should be explained.
  • Aromaticity & aromatic chemistry Concept of aromaticity, Huckel’s rule & its use in determining the aromatic / nonaromatic character of a compound. A brief coverage of structure of benzene. Detailed coverage of electophilic & nucleophilic aromatic substitution reactions. Reactivity & orientation in these reactions. Reactivity & orientation in mono- & disubstituted benzenes. Benzyne mechanism.
  • Different aromatic classes of compounds The following classes of compounds with respect to their IUPAC / systematic nomenclature, industrial [wherever applicable] & laboratory methods of preparations


  • Pharmaceutical Impurities Impurities in pharmaceutical substances, sources, types & effects of impurities. Limit tests for heavy metals like lead, iron, arsenic, mercury & for chloride & sulphate as per Indian Pharmacopoeia [I. P.].
  • Monographs Monograph & its importance, various tests included in monographs as per I. P. A study of the following compounds with respect to their methods of preparation, assay, & pharmaceutical uses: sodium citrate, calcium carbonate, copper sulphate, light & heavy kaolin, ammonium chloride & ferrous gluconate.
  • Isotopes Isotopes- stable & radioactive, mode & rate of decay. Types & measurement of radioactivity. Radiopharmaceuticals & their diagnostic & therapeutic applications in pharmacy & medicine such as 125I, 32P, 51Cr, 60Co, 59Fe, 99Tc-M. Radiocontrast media, use of BaSO4 in medicine.
  • Therapeutic classes of drugs The following topics should be dealt with covering nomenclature [including stereochemical aspects], biological activity [including side & toxic effects ], mode of action, structure activity relationship [where ever applicable] & syntheses of reasonable molecules.
  • Dentifrices, desensitizing agents, & anticaris agents.
  • General anesthetics.
  • Local anesthetics.
  • Antiseptics, disinfectants, sterilants, & astringents.
  • Purgatives, laxatives & antidiarrhoeal agents.
  • Diagnostic agents.
  • Coagulants, anticoagulants & plasma expanders.
  • Drug metabolism Introduction to drug metabolism based on the functional groups.
  • Various classes of therapeutic agents A detailed study of the following classes with respect to drug nomenclature, classification, physicochemical properties, mode of action [MOA], structure activity relationships [SAR], wherever applicable, synthesis of simple & prototype molecules, drug metabolism, therapeutic uses & side effects. Drug resistance, wherever applicable, should be covered in respective classes of drugs. a. Antiamoebic agents. b. Anthelmintic agents. c. Antibacterial sulpha drugs [only]. d. Quinolone antibacterials. e. Antimycobacterial drugs. f. Antifungal agents.
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